Pharmacology assignment Example | Topics and Well Written Essays - 2500 words - 1

Pharmacology - Assignment ExampleHealthy participants lead be assigned to group A and B. subjects in group A were given 50mg of JP234 from mean solar day 3 to day 10 and warfarin 1.5 mg from day 7 to day 14. Participants in group 2 willing receive 1.5 mgs of warfarin from day 3 to 10 and then 50mgs once a day from day 7 to 14. Both medicines will be administered for the first fourteen days while the remain six days will be utilized as washout period. Plasma levels of the drugs will be assessed in both groups. Monitoring the plasma concentration is essential in drug interaction studies. The subjects will be closely monitored for heart activity, clotting factor level and heart rate through function of an electrocardiogram. The drug is believed to be well tolerated during clinical trials and has less contraindication association with it (Simon, 2007). The result of the finding will be utilized in identifying the action of the vernal drug on the metabolism of warfarin. Through blo od try field of battle and the hearts activity measure, the effectiveness and the action of JP234 on warfarin will be measured. The study aims at finding out the effect of JP234 on the action of warfarin. Any changes on the participants will be recorded. Tolerability and the safety of the drug will be assessed too.JP234 is well tolerated during clinical trials and there is no contradiction associated with it. The drug when administered is effective in doses of 50, 75 or 100mg once daily. The drug is metabolized in the liver and has a half life of about 24 hours. In vitro studies indicate that the drug can induce CYP2C9. Patients with chronic atrial fibrillation should be anticoagulated to hinder thromboembolism from taking place (Goodman, 2005). Patient taking JP234 are recommended to take warfarin that is part metabolized by CYP2C9. JP234 is an antiarrhythmic drug and is usually excreted in the liver just the same as warfarin.The new drug is considered an inducer of CYP2C9 whic h takes